Application of Spray Particle Size Analyzer in Pharmaceutical Spray

The spray particle size analyzer (based on laser diffraction) is a core tool for ensuring drug efficacy and safety in the field of pharmaceutical sprays. Its application value is closely related to the core requirements of particle size testing:

1. The Criticality of Particle Size Control

Nebulized drugs must have precisely controlled particle size (1-5 μm for pulmonary administration). Failure to do so can lead to inappropriate drug deposition (too large to be retained in the oropharynx, too small to be exhaled), significantly reducing efficacy or causing local or systemic side effects. Pharmacopeias (USP/EP) worldwide require the provision of particle size distribution data for inhalation preparations.

2. Core Advantages of the Spray Particle Sizer

Real-time, in-situ analysis: Directly measures aerosol in the spray phase, capturing dynamic changes throughout the atomization cycle in milliseconds, providing a true reflection of the patient's inhalation status.

Efficient and Accurate: Wide testing range, outputs key parameters such as Dv50, Span, and FPF, and identifies fine particle proportions and abnormally large droplets.

3. Irreplaceable Application Scenarios

Inhalation dosage form development (pMDI, DPI, nebulizer): Rapidly verify nebulizer device performance and formulation compatibility.

Nasal spray quality control: Ensure particle size within the 30-100μm range to avoid lung deposition risk.

Therefore, the spray particle size analyzer is the core equipment for the research and development, production and application evaluation of pharmaceutical spray. A high-performance laser particle size analyzer has the advantages of easy operation, fast test speed, good repeatability and accuracy. This time, Winner311PRO is recommended to test the particle size distribution of pharmaceutical spray for customers.

Winner 311PRO can be used for particle size testing of liquid spray or mist powder. It can perform non-contact particle size measurement droplets, liquid droplets, smoke, aerosol, powder mist, etc. Dispersed in the air.It can also be used for product development and quality control in industries such as medicine, petrochemicals, environmental monitoring, aesthetic medicine and aromatherapy.

Measuring instrument information is as follows:

The video of measuring nanoparticles is as follows：