Application of Laser Particle Size Analyzer in Rifampicin Powder

Rifampicin is a broad-spectrum antibiotic that belongs to the rifamycin class of drugs. It is one of the key drugs used to treat tuberculosis (TB) and is also used to treat certain other bacterial infections.

Strictly monitoring the particle size distribution of rifampicin is a key step in ensuring its stable dissolution, effective absorption, uniform quality, and process control. Laser particle size analyzers play a key role in controlling the particle size distribution of rifampicin:

1. Optimizing Dissolution and Efficacy

Rifampicin is a poorly soluble drug, and its bioavailability depends on the particle surface area. Laser particle size analysis accurately measures particle size distribution (such as D50, D90) and rapidly identifies micronized particles (1-50μm). This ensures a high proportion of fine particles, accelerates dissolution, and avoids the risk of treatment failure or drug resistance caused by insufficient absorption due to overly large particles.

2. Ensure consistent production quality

Through dry/wet dispersion technology, the particle size uniformity (such as span value) of raw materials and intermediates is monitored in real time. Batch-to-batch distribution variability is strictly controlled to ensure powder flowability, dosage form content uniformity, and suspension stability, while minimizing precipitation and agglomeration.

3. Support process and regulatory compliance

Efficient non-destructive testing (completed in seconds) meets online quality control needs. Accurate reports compliant with USP/ISO pharmacopoeias are provided to verify pulverization process stability, ensure GMP compliance, and control drug safety and effectiveness from the source.

Laser particle size analyzer offers high precision and efficiency in resolving dissolution bottlenecks and production risks associated with rifampicin particle size. It is a key quality control tool for ensuring anti-tuberculosis efficacy. This time, Winner3003 is recommended to test the particle size distribution of rifamycin powder for customers.

Winner3003 is the new generation intelligent dry small-range particle size analyzer. It features a modular design, intelligent one-button operation, an independent dry dispersion system, and unconstrained free-fitting technology. It is suitable for testing the particle size distribution of dry powder materials, especially those that undergo morphological changes in liquids.

Measuring instrument information is as follows:

The video of measuring particles is as follows：